professor Lein-Tuan Hou

Education

• DDS, National Taiwan University 1973
• National Taiwan University, Department of Periodontology, 1979
• Ph.D. in Oral Biology, University of Connecticut, 1987

Experience

• Chair, Taiwan Academy of Periodontology
• Director of the Department of Periodontology, National Taiwan University Hospital

1. Cellular biological study of drug-induced gingival enlargement
2. Drug-induced gingival enlargement secondary to organ transpla-ntation has increased recently in Taiwan. Currently, my lab is collecting clinical cases, growing cells in culture from surgical biopsy specimens. Analysis of the growth curve, DNA synthesis, protein metabolism, tissue remodeling mechanism involving the role of metaloproteinases and their inhibitors from each isolated cell lines are also undertaken.
3. Role of interleukin in the pathogenesis of periodontal diseases
4. Interleukin has been implicated as a preinflammatory mediator, which is one of the most potent inducer of bone resorption and soft tisue resolution. The concentration of interleukin-1b in inflammed periodontal tissues, localization of types of cells producing 1L-1B and their presence with the severity of overt periodontitis are currently investigated.

1. L.-T Hou (1993) Study of Collagen and Fibronection in Fibroblasts Derived from Healthy and Diseased Periodontal Tissues. J Formosan Med. Asso. 92: 367-372
2. L.-T Hou, C.-M Liu and Wen-Kuei Chang (1994) Alkaline Phosphatase Activity in Cultured Cells of Healthy and Hyperplastic Gingivae. J Formosan Med Asso. 93 (10):870-74.
3. L.-T Hou and J.A Yaeger (1995) Alkaline Phosphatase Expression in Cells lsolated from Different Overgrown Gingival Tissues. J Oral Path Mcd 24:97-102.
4. L.-T Hou, C.-M Liu, and W.-K Chang (1994) Increased interleukin-1b in Gingival Crevicular Fluid of Chinese Periodontal patients. J Formosan Med Asso. 93:99-103.
5. L.-T Hou, C.-M Liu and E.F Rossomando (1995): Crevicular interleukin-1B in moderate and severe periodontitis patients and the effect of phase I periodontal treatment. J Clin Periodontol 22 (2): 162-167.
6. C-M Liu, L-T Hou, M-Y Wong and E F, Rossomando (1996) Relationship among clinical parameters, interleukin-1b and histopathologic findings of gingival tissue in periodontitis patients. Cytokine 8: 168-177, 1996.