Emeritus Professor Chun-Pin Chiang

• D.D.S., Dentistry, National Taiwan University, 1977
• D.M.Sc., Oral Pathology, Harvard School of Dental Medicine, 1989

1. Immunohistochemistry of oral lesions: This study primarily investigated the expression of oncogenes, tumor suppressor genes, growth factors, growth factor receptors, and cytokeratin in oral precancerous lesions, oral cancer, salivary gland tumors, odontogenic cysts, and odontogenic tumors using single or multiple antibodies and immunohistochemical staining methods. The study will greatly contribute to understanding the malignant potential of oral precancerous lesions and the pathogenesis of oral lesions.
2. Photodynamic diagnosis and treatment of oral precancerous and cancerous lesions: In recent years, we have developed autofluorescence spectroscopy and dye fluorescence spectroscopy, including 5-ALA-guided protoporphyrin IX (PpIX) fluorescence spectroscopy, to assist in the diagnosis of oral precancerous and cancerous lesions. Our studies have shown that autofluorescence spectroscopy using excitation light at 330 nm and ALA-guided PpIX fluorescence spectroscopy using excitation light at 410 nm can help distinguish oral submucous fibrosis (OSF), normal oral mucosa, oral precancer, and oral cancer. Therefore, these fluorescence spectroscopy techniques may help determine appropriate biopsy sites in large areas of oral leukoplakia or erythroplakic lesions. In addition, photodynamic therapy with topical application of 20% ALA can be used as an adjuvant therapy for oral precancerous lesions and oral cancer. Our research has found that it has good therapeutic effects on verrucous hyperplasia and erythroplakia and may have potential for treating verrucous carcinoma and early-stage oral cancer.

Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM, Chiang CP (2016). Do all the patients with vitamin B12 deficiency have pernicious anemia? Journal of Oral Pathology & Medicine 45:23-7.(SCI)

Sun A, Chang JYF, Chiang CP (2016). Blood examination is necessary for oral mucosal disease patients. Journal of the Formosan Medical Association 115:1-2.(SCI)

Cheng SJ, Chen HM and Chiang CP (2015). Cryogun cryotherapy is the first-line treatment of choice for oral leukoplakia. Journal of Dental Sciences 10: 223-224. (SCI)

Chiang ML, Hsieh YJ, Tseng YL, Lin JR and Chiang CP (2014). Oral mucosal lesions and developmental anomalies in dental patients of a teaching hospital in Northern Taiwan. Journal of Dental Sciences 9: 69-77. (SCI)

Shen WR, Wang YP, Chang JYF, Yu SY, Chen HM and Chiang CP (2014). Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine 43: 258-264. (SCI)

Sun A, Lin HP, Wang YP, Chen HM, Cheng SJ, Chiang CP (2013). Significant reduction of serum homocysteine level and oral symptoms after different vitamin supplement treatments in patients with burning mouth syndrome. Journal of Oral Pathology & Medicine doi: 10.1111/jop.12043 (SCI)

Cheng SJ, Liu YC, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MYP, Chiang CP (2013). Expression of G�12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine DOI: 10.1111/jop.12050. (SCI)

Lee JJ, Cheng SJ, Wang YP, Jeng JH, Chiang CP, Kok SH (2013). Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases. Head & Neck 35(1):E6-E10. (SCI)

Cheng SJ, Kok SH, Lee JJ, Kuo MYP, Cheng SL, Huang YL, Chen HM, Chang HH, Chiang CP (2012). Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 34(9):1340-45. (SCI)

1. Sun AD, Lin HP, Wang YP, Chiang CP (2012). Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. Journal of Oral Pathology & Medicine 41(6):500-04. (SCI)